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IFITM1 Human shRNA Plasmid Kit (Locus ID 8519)

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SKU
TG312242
IFITM1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 8519
Synonyms 9-27; CD225; DSPA2a; IFI17; LEU13
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IFITM1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 8519). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_003641, NM_003641.1, NM_003641.2, NM_003641.3, BC000897, NM_003641.4
UniProt ID P13164
Summary IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins
Zhang, Zhang, Zan et al
J. Gen. Virol. (2014)
Cited by 45
AI Summary: OriGene’s shRNA plasmids targeting Ifitm1-3 genes were used to generate IFITM protein knockdown cell lines, enabling the study of these proteins’ roles in inhibiting respiratory syncytial virus infection.
Snippet: IFITM proteins knockdown cell lines were established by transfecting cells with 410 shRNA plasmids (OriGene) targeting each of the Ifitm1-3 genes, and then selected under 411 puromycin (4 μg/ml) for 2 weeks
Showing 1-1 of 1 papers.
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