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KRT6A Human shRNA Plasmid Kit (Locus ID 3853)

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SKU
TG311830
KRT6A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 3853
Synonyms CK-6C; CK-6E; CK6A; CK6C; CK6D; K6A; K6C; K6D; KRT6C; KRT6D; PC3
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components KRT6A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 3853). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_005554, NM_005554.1, NM_005554.2, NM_005554.3, BC014152, BC014152.2, BC008807, BC069269, BC125058, BC139753, NM_005554.4
UniProt ID P02538
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. provided by RefSeq, Oct 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

K16 is a further new candidate for homotypic intermediate filament protein interactions
Trost, Costa, Jakab et al
Exp Dermatol (2010) 19 (8), e241-50 DOI: 10.1111/j.1600-0625.2010.01071.x
Cited by 6
AI Summary: OriGene products, specifically the KRT16 cDNA clone and KRT16 antibody, were used in this study to express and detect cytokeratin 16 (K16), enabling the authors to demonstrate that K16 can form homodimers, identifying it as a new candidate for homotypic intermediate filament protein interactions.
Showing 1-1 of 1 papers.
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