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LOXL2 Human shRNA Plasmid Kit (Locus ID 4017)

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SKU
TG311699
LOXL2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4017
Synonyms LOR; LOR2; WS9-14
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components LOXL2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4017). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_002318, NM_002318.1, NM_002318.2, BC000594, BC000594.2, BC020481, NM_002318.3
UniProt ID Q9Y4K0
Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of its catalytic activity
Almacellas-Rabaiget, Monaco, Huertas-Martinez et al
Cancer Lett (2020) 474, 1-14 DOI: 10.1016/j.canlet.2019.12.040
Cited by 20
AI Summary: In this study, OriGene products—including the LOXL2 cDNA clone (RC219307) and LOXL2 shRNA constructs (TR313455, TR313456)—were used to manipulate LOXL2 expression in rhabdomyosarcoma cell lines, enabling the investigation of LOXL2’s role in tumor progression and metastasis.
LOXL2 Promotes Oncogenic Progression in Alveolar Rhabdomyosarcoma Independently of its Catalytic Activity
Almacellas-Rabaiget, Monaco, Huertas-Martinez et al
Cancer Lett. (2020) 474, 1-14 DOI: 10.1016/j.canlet.2019.12.040
Cited by 20
AI Summary: OriGene’s pRS-shLOXL2 vector (#TG311699) was used to stably knock down LOXL2 expression in RH4 and CW9019 cell lines, enabling the study of LOXL2’s role in cell migration and invasion in alveolar rhabdomyosarcoma.
Snippet: … RH4 and CW9019 cells stably expressing pRS-shLOXL2 vector (Origene, Rockville, MD, USA #TG311699) were selected with 0.6 μg/mL and 0.25 μg/mL of puromycin (Sigma-Aldrich, St. … RH4 and CW9019 cells stably expressing pRS-shLOXL2 vector (Origene, Rockville, MD, USA #TG311699) were selected with 0.6 μg/mL and 0.25 μg/mL of puromycin (Sigma-Aldrich, St. … RH28 transfected cells stably expressing pCDNA3-LOXL2wt FLAG tagged vector or pCDNA3-LOXL2oxmut FLAG tagged vector (gifts from Dr. Sandra
Showing 1-2 of 2 papers.
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