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MBD4 Human shRNA Plasmid Kit (Locus ID 8930)

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SKU
TG311558
MBD4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 8930
Synonyms MED1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MBD4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 8930). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001276270, NM_001276271, NM_001276272, NM_001276273, NM_003925, NM_003925.1, NM_003925.2, NM_001276273.1, NM_001276272.1, NM_001276271.1, NM_001276270.1, BC011752, BC034463, NM_001276270.2, NM_001276272.2, NM_003925.3
UniProt ID O95243
Summary The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, Jan 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4
Zhang, Yang, Zhang et al
Cancer Med (2018)
AI Summary: OriGene products, specifically shRNAs targeting human MBD4 (shMBD4) and negative control shRNAs (shNC), were used to knock down endogenous MBD4 expression and investigate its role in the epigenetic silencing of RNF144A in breast cancer cells.
Snippet: 5000. Knockdown of endogenous MBD4 by short hairpin RNAs Short hairpin RNAs (shRNAs) targeting human MBD4 (shMBD4) and negative control shRNAs (shNC) were pur- chased from Origene (Rockville, MD). For lentiviral
CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor
Nodomi, Umeda, Saida et al
Oncogene (2016)
Cited by 25
AI Summary: OriGene products, specifically the CD146 shRNA plasmids (TG311550A, shRNA#1; TG311550D, shRNA#2) and the scrambled control shRNA plasmid (TR30013), were used in this study to knock down CD146 expression and investigate its role in tumor growth and tumorigenicity in malignant rhabdoid tumor cells.
Snippet: Transfection with CD146 shRNA. Two distinct shRNA plasmids targeting human CD146 mRNA (TG311550A, shRNA#1;TG311550D, shRNA#2) and a scrambled control shRNA plasmid (TR30013, scrambled shRNA) were purchased from OriGene (Rockville, MD, USA ... Cite SaveSaving
Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes
Suzuki, Emura, Fukushima
Int. J. Oncol. (2011) 39 (1), 263-70 DOI: 10.3892/ijo.2011.1003
Cited by 46
AI Summary: OriGene products contributed shRNA constructs against TDG (cat. no. TG316755) and MBD4 (cat. no. TG311558) in pGFP-V-RS vectors, which were used to knock down these genes in HeLa cells to study their roles in the cytotoxic effects of trifluorothymidine.
Snippet: immunoprecipitation in Materials and methods. shRNA. shRNA constructs against TDG (cat. no. TG316755) and MBD4 (cat. no. TG311558) in pGFP-V-RS vectors were obtained from Origene Technologies Inc. (MD, USA). The HeLa cells in 6
Showing 1-3 of 3 papers.
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