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MMP7 Human shRNA Plasmid Kit (Locus ID 4316)

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SKU
TG311438
MMP7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4316
Synonyms MMP-7; MPSL1; PUMP-1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MMP7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4316). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC003635, NM_002423, NM_002423.2, NM_002423.3, NM_002423.4, BC003635.2, NM_002423.5
UniProt ID P09237
Summary This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression
Felli, Errico, Pedini et al
Oncogene (2016) 35 (23), 3016-26 DOI: 10.1038/onc.2015.357
Cited by 19
AI Summary: In this paper, OriGene products such as the AP2α cDNA clone (RC209866) and AP2α shRNA (TL311323) were used to manipulate AP2α expression levels, enabling the authors to investigate its regulatory role in balancing miR-126&126* and miR-221&222 during melanoma progression.
FigureFigureFigure
miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma
Felli, Felicetti, Lustri et al
PLoS ONE (2013) 8 (2), e56824 DOI: 10.1371/journal.pone.0056824
Cited by 89
AI Summary: OriGene products contributed to this study by providing 29-mer shRNA constructs (#TG314947 for ADAM9, #TG311438 for MMP7, and #TR30013 as a scrambled negative control) used to specifically silence ADAM9 and MMP7 genes, enabling the researchers to investigate the tumor suppressor role of miR-126&126* in melanoma.
Snippet: Gene silencing. ADAM9 and MMP7 silencing was performed by using 4 unique 29-mer shRNA constructs in retroviral GFP vector, #TG314947 for ADAM9, #TG311438 for MMP7 and #TR30013 for scrambled negative control (OriGene Technologies, Rockville, MD, USA).
AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression
Felli, Errico, Pedini et al
Oncogene (2015)
AI Summary: OriGene products, specifically the 29-mer shRNA constructs #TG314947 (ADAM9), #TG311438 (MMP7), and #TR30013 (scrambled control), were used for gene silencing experiments to investigate the roles of ADAM9 and MMP7 in melanoma progression.
Snippet: ADAM9 and MMP7 silencing was performed by using four unique 29-mer shRNA constructs in retroviral GFP vector, #TG314947 for ADAM9, # TG311438 MMP7 and #TR30013 for scrambled negative control (OriGene Technologies, Rockville, MD, USA)
Showing 1-3 of 3 papers.
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