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MYD88 Human shRNA Plasmid Kit (Locus ID 4615)

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SKU
TG311320
MYD88 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Other products for "MYD88 or NM_001172566"

Specifications
Specifications
Product Data
Locus ID 4615
Synonyms IMD68; MYD88D
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MYD88 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4615). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001172566, NM_001172567, NM_001172568, NM_001172569, NM_002468, NM_002468.2, NM_002468.3, NM_002468.4, NM_001172566.1, NM_001172569.1, NM_001172568.1, NM_001172567.1, BC013589, BC013589.1, NM_001365877, NM_001365876, NM_002468.5
UniProt ID Q99836
Summary This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. provided by RefSeq, Feb 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis
Pal, Daniels, Oskman et al
MBio (2016) 7 (3) DOI: 10.1128/mBio.00617-16
AI Summary: OriGene products contributed to this study by providing shRNAs targeting Myd88 (TG311320), NFκB (TR318700), caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), and TLR2 (TR320553), which were used to investigate the molecular pathways involved in HRPII-induced disruption of brain endothelial barriers.
Snippet: Cells were then incubated for 36 h. HRPII was then added, and TEER measurements were recorded over 24 h. shRNAs for each gene were purchased from Origene as follows: for the Myd88 gene, TG311320;for the NFκB gene, TR318700;for the caspase-1 gene, TG305640;for the TLR9 gene, TR301076;for the TLR5 gene, TR308792;and for the TLR2 gene, TR320553
Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88
Lee, Miyata, Lim et al
PNAS (2016) 113 (2), E165-71 DOI: 10.1073/pnas.1518615113
Cited by 42
AI Summary: In this study, OriGene’s human shRNAs for MyD88 were used to specifically knock down MyD88 expression, enabling the authors to investigate the regulatory role of CYLD in NTHi-induced inflammation.
Snippet: previously (31). RNA-Mediated Interference. RNA-mediated interference for down-regulating CYLD expression was carried out by using pSuper-shCYLD (8). Human shRNAs for MyD88 were purchased from Origene. Human ... Cite SaveSaving
The Role of Histidine Rich Protein II in Cerebral Malaria
Pal
Thesis (2017)
Snippet: …shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFкB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency in pilot studies
The Role of Histidine Rich Protein II in Cerebral Malaria Pathogenesis
Pal
Thesis (2017)
Snippet: shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency ... Cite SaveSaving
Showing 1-4 of 4 papers.
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