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PTPN12 Human shRNA Plasmid Kit (Locus ID 5782)

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SKU
TG310066
PTPN12 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Other products for "PTPN12 or NM_001131008"

Specifications
Specifications
Product Data
Locus ID 5782
Synonyms PTP-PEST; PTPG1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTPN12 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 5782). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001131008, NM_001131009, NM_002835, NM_002835.1, NM_002835.2, NM_002835.3, NM_001131009.1, NM_001131008.1, BC050008, BC050008.1, BC026004, NM_001131008.2, NM_001131009.2, NM_002835.4
UniProt ID Q05209
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Oct 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12
Rhee, Davidson, Souza et al
Mol. Cell. Biol. (2013) 33 (12), 2458-69 DOI: 10.1128/MCB.00197-13
AI Summary: OriGene’s pRS-Puro shRNA expression vector was used to downregulate PTP-PEST expression in RAW264.7 macrophage cells, enabling the authors to investigate the role of PTP-PEST in macrophage fusion.
Snippet: For downregulation of PTP-PEST expression in RAW264.7 cells, cells were infected with a retrovirus encoding the Ptpn12-specific small hairpin RNA (shRNA) expression vector pRS-Puro (Origene, Rockville, MD) following the protocol of the manufacturer.
Showing 1-1 of 1 papers.
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