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Stromal interaction molecule 1 (STIM1) Human shRNA Plasmid Kit (Locus ID 6786)

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SKU
TG309049
STIM1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 6786
Synonyms D11S4896E; GOK; IMD10; STRMK; TAM; TAM1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components STIM1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 6786). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001277961, NM_001277962, NM_003156, NM_003156.1, NM_003156.2, NM_003156.3, NM_001277962.1, NM_001277961.1, BC021300, BC019905, BM127091, NM_001277961.3, NM_001277962.2, NM_003156.4
UniProt ID Q13586
Summary This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. provided by RefSeq, May 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion
Shalygin, Kolesnikov, Glushankova et al
Cell Calcium (2021) 97, 102432 DOI: 10.1016/j.ceca.2021.102432
Cited by 23
AI Summary: OriGene shRNA plasmids targeting STIM1, Orai1, and Orai3 were used in this study to knock down these proteins and investigate their roles in regulating TRPC1 channel activity upon calcium store depletion.
Snippet: For STIM1, Orai1, or Orai3 knockdown, the cells were transiently transfected with shRNA plasmid from OriGene Technologies, Rockville, MD, USA (STIM1 shRNA 5′-CTGAGCAGAGTCTGCATGACCTTCAGGAA-3′;Orai1 shRNA5
Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid
Levin Gromiko, Koshelev, Kushnir et al
Carcinogenesis (2014)
Cited by 26
AI Summary: OriGene contributed Stim1 (murine: TI336190) shRNA-encoding plasmids to this study, enabling targeted gene knockdown to investigate the role of Stim1 in melanoma cell signaling and response to zoledronic acid.
Snippet: NFAT2 (murine: TRCN0000081923;human: TRCN0000017333) and Stim1 (murine: TI336190) small hairpin RNA (shRNA)-encoding plasmids were purchased from Sigma and Origene (Rockville, BD), respectively. Renilla ... Cite SaveSaving
Molecular mechanisms of spontaneous and directed mast cell motility
Lee, Veatch, Baird et al
J. Leukoc. Biol. (2012) 92 (5), 1029-41 DOI: 10.1189/jlb.0212091
Cited by 26
AI Summary: OriGene’s shRNA plasmids targeting Orai1, STIM1, and TRPC1 were used in this study to investigate how these Ca(2+) channel proteins contribute to mast cell motility and chemotaxis.
Snippet: shRNA plasmids targeting Orai1, STIM1, and TRPC1 (OriGene, Rockville, MD, USA) were described previously and characterized in RBL cells [39]. GCaMP3 [40] and R-GECO 1 [41] constructs were obtained from Addgene (Cambridge, MA, USA). Cell culture.
Showing 1-3 of 3 papers.
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