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ARID1A Human shRNA Plasmid Kit (Locus ID 8289)

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SKU
TG306603
ARID1A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 8289
Synonyms B120; BAF250; BAF250a; BM029; C1orf4; CSS2; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components ARID1A - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 8289). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_006015, NM_018450, NM_139135, NM_006015.1, NM_006015.2, NM_006015.3, NM_006015.4, NM_139135.1, NM_139135.2, BC112895, NM_139135.4, NM_006015.6
UniProt ID O14497
Summary This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment
Nettersheim, Jostes, Fabry et al
Oncotarget (2016)
Cited by 61
AI Summary: OriGene products contributed to this study by providing the GADD45B cDNA coding plasmid and four different ARID1A shRNAs (encoded in the pGFP-V-RS vector), which were used to investigate the roles of these genes in germ cell cancer cell response to romidepsin treatment.
Snippet: The GADD45B cDNAcoding plasmid was obtained from Origene (via Biocat, Heidelberg, Germany). For retroviral transduction of TCam-2 cells, four different ARID1A shRNAs encoded in the pGFP-V-RS vector were utilized (Origene, via BioCat, Heidelberg, Germany)
BAF complexes facilitate decatenation of DNA by topoisomerase IIα
Dykhuizen, Hargreaves, Miller et al
Nature (2013) 497 (7451), 624-7 DOI: 10.1038/nature12146
Cited by 279
AI Summary: In this paper, OriGene products such as the BRG1 (SMARCA4) expression plasmid and BRG1 (SMARCA4) shRNA were used to manipulate BRG1 levels in cells, enabling the authors to investigate the role of BAF complexes in facilitating DNA decatenation by topoisomerase IIα.
Snippet: Recent exon-sequencing studies of human tumours have revealed that subunits of BAF (mammalian SWI/SNF) complexes are mutated in more than 20% of all human malignancies, but the mechanisms involved in tumour suppression are unclear. BAF chromatin-remodelling
Showing 1-2 of 2 papers.
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