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DUSP10 Human shRNA Plasmid Kit (Locus ID 11221)

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SKU
TG304883
DUSP10 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 11221
Synonyms MKP-5; MKP5
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components DUSP10 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 11221). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_007207, NM_144728, NM_144729, NR_111939, NR_111940, NM_007207.2, NM_007207.3, NM_007207.4, NM_007207.5, NM_144729.1, NM_144729.2, NM_144728.1, BC031405, BC031405.1, BC020608, BC063826, NM_007207.6
UniProt ID Q9Y6W6
Summary Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma
Benavides-Serrato, Anderson, Holmes et al
Genes Cancer (2014) 5 (11-12), 393-406
Snippet: PTEN antibodies and protein phosphatase lambda were from Millipore. DKK antibodies were from Origene. All other reagents were obtained from Sigma. ... DUSP10 shRNA constructs were also obtained from OriGene cloned into the retroviral vector pRS. ... Related articles All 4 versions Cite SaveSaving
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Showing 1-1 of 1 papers.
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