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EZH2 Human shRNA Plasmid Kit (Locus ID 2146)

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SKU
TG304713
EZH2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2146
Synonyms ENX-1; ENX1; EZH2b; KMT6; KMT6A; WVS; WVS2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components EZH2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2146). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001203247, NM_001203248, NM_001203249, NM_004456, NM_152998, NM_004456.1, NM_004456.2, NM_004456.3, NM_004456.4, NM_152998.1, NM_152998.2, NM_001203249.1, NM_001203248.1, NM_001203247.1, BC010858, BC010858.2, BM974565, NM_001203249.2, NM_001203247.2, NM_004456.5, NM_001203248.2, NM_152998.3
UniProt ID Q15910
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Feb 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

miR‑92b promotes autophagy and suppresses viability and invasion in breast cancer by targeting EZH2
Liu, Sang, Meng et al
Int. J. Oncol. (2018)
AI Summary: OriGene products, including the GFP-LC3 plasmid, EZH2 shRNA plasmid, pCMV6 Entry-EZH2-Myc-DDK expression plasmid, and control plasmid, were used in this study to manipulate and analyze EZH2 expression and autophagy in breast cancer cells.
Snippet: (Shanghai, China). Green fluorescent protein (GFP)-light chain 3 (LC3), EZH2 short hairpin (sh)-RNA Plasmid, pCMV6 Entry-EZH2- Myc-DDK expression plasmid and control plasmid were purchased from OriGene Technologies, Inc. (Rockville, MD, USA)
C-type lectin-like domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen
Takahashi, Watanabe, Watanabe et al
FEBS Lett. (2015)
Cited by 31
AI Summary: OriGene products contributed to this study by providing the anti-DDK antibody and the mouse PLA2R cDNA (NM_007366.4), which were used for detecting and expressing PLA2R constructs in the experiments.
Snippet: 1 and Fig. 2). Antibody against CTLD2-3 of mouse PLA 2 R (clone 912F) was prepared as described in our previous reports [10] and [19]. Anti-DDK antibody was from OriGene (Rockville, MD, USA). ... NM_007366.4) was purchased from OriGene. ... Cite SaveSaving
EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis
Zhang, Garnett, Creighton et al
J. Pathol. (2013)
Cited by 62
AI Summary: OriGene products contributed to this study by providing two EZH2 shRNA constructs (GI318845, GI318846) for gene knockdown experiments and a KPNB1 constitutive expression construct for overexpression studies, enabling the authors to dissect the roles of EZH2 and KPNB1 in MPNST cell survival and tumorigenesis.
Snippet: scrambled negative control or two different EZH2 shRNA targeting constructs (GI318845, GI318846, Origene) were transfected into MPNST cells with lipofectamine 2000 (Invitrogen) ... KPNB1 constitutive expression construct was purchased from Origene.
Showing 1-3 of 3 papers.
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