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Klotho (KL) Human shRNA Plasmid Kit (Locus ID 9365)

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SKU
TG303679
KL - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 9365
Synonyms HFTC3
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components KL - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 9365). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_004795, NM_153683, NM_004795.1, NM_004795.2, NM_004795.3, NM_153683.2
UniProt ID Q9UEF7
Summary This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice
Long, Shi, Zhou et al
Eur. J. Pharmacol. (2017) 820, 198-205 DOI: 10.1016/j.ejphar.2017.12.019
AI Summary: OriGene products, specifically the recombinant lentiviral vectors LV-KL shRNA and LV-GFP, were used to manipulate klotho gene expression in mice, enabling the study to demonstrate klotho’s role in ligustilide-mediated neuroprotection against cerebral ischemic injury.
Snippet: gene I (RIG-1), NF-κB p65, lamin B and β-actin are summarized in Table 1. Recombinant lentiviral vectors harboring a short-hairpin RNA (shRNA) sequence targeting klotho (LV-KL shRNA) and its scramble vector (LV-GFP) were purchased from OriGene (Rockville
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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