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MCL1 Human shRNA Plasmid Kit (Locus ID 4170)

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SKU
TG303313
MCL1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4170
Synonyms bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MCL1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4170). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001197320, NM_021960, NM_182763, NM_021960.1, NM_021960.2, NM_021960.3, NM_021960.4, NM_182763.1, NM_182763.2, NM_001197320.1, BC017197, BC017197.2, BC071897, BC107735, NM_021960.5
UniProt ID Q07820
Summary This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. provided by RefSeq, Oct 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis
Nolan, Walter, Tuffy et al
Eur. J. Neurosci. (2016)
Cited by 38
AI Summary: OriGene products contributed to this study by providing the shRNA vector targeting human Mcl-1 (pGFP-V-RS, TG303313), the pCMV6-Mcl-1 overexpression vector, and the pCMV-pre-miRNA29a vector, which were used to manipulate gene expression and investigate the roles of Mcl-1 and miR-29a in ER stress-induced neuronal apoptosis.
Snippet: The shRNA vector targeting human Mcl-1 (pGFP-V-RS, TG 303313), the pCMV6-Mcl-1 overexpression vector and the pCMV-pre-miRNA29a vector were purchased from Origene (Rockville, Maryland, USA) and the pcDNA3.1 control empty vector was purchased from ... Cite SaveSaving
Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis
Murphy, Weyhenmeyer, Noonan et al
Apoptosis (2013)
Cited by 48
AI Summary: OriGene’s human Mcl-1 and Noxa knockdown 29mer shRNA constructs in retroviral GFP vectors were used to silence these genes in glioblastoma cells, enabling the study to demonstrate how targeting Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis.
Snippet: A172, U87 and MZ-294 cells were transfected with human Mcl-1 knockdown 29mer shRNA construct in a retroviral GFP vector (Origene) and MZ-294 cells were transfected with human Noxa knockdown 29mer shRNA construct in a retroviral GFP vector (Origene) using ... Cite SaveSaving
Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway
Premkumar, Jane, Foster et al
J. Pharmacol. Exp. Ther. (2013) 346 (2), 201-10 DOI: 10.1124/jpet.113.204743
Cited by 28
AI Summary: OriGene contributed 29mer-pRS-shRNA constructs used for transient transfection to knock down specific gene expression in glioma cells, enabling the study of how gene silencing (such as Mcl-1 and Noxa) affects sensitivity to TRAIL and YM-155-induced apoptosis.
Snippet: Soluble human recombinant SuperKillerTRAIL (referred as TRAIL in this manuscript) was purchased from Enzo Biochemicals (Enzo Life Sciences, Farmingdale, NY). ... 9 Transient transfection Optimal 29mer-pRS-shRNA constructs were obtained from Origene (Rockville, MD).
YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context
Jane, Premkumar, DiDomenico et al
Mol. Cancer Ther. (2013) 12 (3), 326-38 DOI: 10.1158/1535-7163.MCT-12-0901
Cited by 3
AI Summary: OriGene contributed to this study by providing the 29mer-pRS-shRNA constructs used for transient transfection to downregulate Mcl-1, helping to demonstrate the role of Mcl-1 in glioma cell resistance and the synergistic effects of YM-155 and ABT-737.
Snippet: Scanning densitometry was conducted using acquisition into Adobe Photoshop (Adobe Systems, Inc.) followed by image analysis (UN-SCAN-IT gel, version 6.1;Silk Scientific). Transient transfection. Optimal 29mer-pRS-shRNA constructs were obtained from Origene.
Showing 1-4 of 4 papers.
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