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NDRG4 Human shRNA Plasmid Kit (Locus ID 65009)

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SKU
TG303003
NDRG4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 65009
Synonyms BDM1; SMAP-8; SMAP8
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components NDRG4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 65009). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001130487, NM_001242833, NM_001242834, NM_001242835, NM_001242836, NM_020465, NM_022910, NR_040072, NM_020465.1, NM_020465.2, NM_020465.3, NM_001130487.1, NM_001242836.1, NM_001242835.1, NM_001242834.1, NM_001242833.1, NM_022910.1, NM_022910.2, NM_022910.3, BC001527, BC011795, NM_001363869, NM_001130487.2, NM_022910.4, NM_020465.4
UniProt ID Q9ULP0
Summary This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.provided by RefSeq, Jun 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients
Jandrey, Moura, Andrade et al
NPJ Breast Cancer (2019) 5, 11 DOI: 10.1038/s41523-019-0106-x
AI Summary: OriGene products contributed to this study by providing NDRG4 shRNA lentiviral particles used for gene knockdown experiments to investigate the functional effects of NDRG4 silencing on breast cancer cell adhesion and migration.
Snippet: differences in growth curves in vitro or in the incidence of tumors or tumor growth in orthotopic mouse models (Supplementary Fig. S3), indicating that NDRG4 silencing has no significant effect on tumorigenesis or cell proliferation in vitro and in vivo. Similarly, the poor invasive behavior of the MCF-7 cell line cultured as 3D spheroids was not affected by NDRG4 knockdown (data not shown). Howev
FigureFigureFigure
Showing 1-1 of 1 papers.
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