NOTCH2 Human shRNA Plasmid Kit (Locus ID 4853)
SKU
TG302915
NOTCH2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 4853 |
|---|---|
| Synonyms | AGS2; HJCYS; hN2 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | NOTCH2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4853). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | NM_001200001, NM_024408, NM_024408.1, NM_024408.2, NM_024408.3, NM_001200001.1, BC071562, NM_024408.4 |
| UniProt ID | Q04721 |
| Summary | This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2011 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo
Li, He, Tian et al
Mol Med Rep (2014) 10 (6), 2843-50 DOI: 10.3892/mmr.2014.2661
Li, He, Tian et al
Mol Med Rep (2014) 10 (6), 2843-50 DOI: 10.3892/mmr.2014.2661
Cited by 16
AI Summary: OriGene contributed to this study by providing the pGFP-V-RS Notch2 shRNA plasmid, which was used to stably knock down Notch2 expression in U87 human glioma cells to investigate its effects on cell proliferation, cell cycle, and apoptosis.
Snippet: 85-23, revised 1996). Construction and identification of U87 cells stably transfected with plasmids. The p green fluorescent protein (GFP)-V-RS Notch2 short hairpin RNA (shRNA) plasmid was purchased from Beijing OriGene Technologies Co., Ltd. (Beijing, China). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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