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SETD4 Human shRNA Plasmid Kit (Locus ID 54093)

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SKU
TG301750
SETD4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 54093
Synonyms C21orf18; C21orf18, C21orf27; C21orf27; OTTHUMP00000108890; OTTHUMP00000108895; SET domain containing 4
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SETD4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 54093). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001007258, NM_001007259, NM_001007260, NM_001007261, NM_001007262, NM_001286752, NM_017438, NR_040086, NR_040087, NR_040088, NM_001007259.1, NM_001007259.2, NM_017438.1, NM_017438.2, NM_017438.3, NM_017438.4, NM_001007261.1, NM_001007261.2, NM_001286752.1, NM_001007262.1, BC002898, BC002898.2, BC036556, NM_017438.5, NM_001286752.2
UniProt ID Q9NVD3
Summary Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

SET domain-containing Protein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyltransferase involved in Breast Cancer Cell Proliferation
Faria, Corrêa, de Andrade et al
J Cancer Sci Ther (2013) 5 (2), 58-65
FigureFigureFigure
SET domain-containing Protein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyltransferase involved in Breast Cancer Cell Proliferation
Arantes Faria, Resende Corrêa
J Cancer Sci Ther (2013) 5 (2)
Snippet: MDA-MB 231 cells were transfected with shSETD4 (TG301750;OriGene, Rockville, MD, USA) using Lipofectamine 2000 (Life Technologies). Stable clones were selected using 800 µg/ml G418 (Sigma-Aldrich) for 14 days. Tumor specimens
Showing 1-2 of 2 papers.
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