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Vegfa Rat shRNA Plasmid (Locus ID 83785)

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SKU
TF711624
Vegfa - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 83785
Synonyms Vegf; VEGF-A; VEGF111; VEGF164; VPF
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Vegfa - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 83785). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001110333, NM_001110334, NM_001110335, NM_001110336, NM_001287107, NM_001287108, NM_001287110, NM_001287111, NM_001287112, NM_001287113, NM_001287114, NM_031836, NR_105011, NM_001110336.1, NM_031836.1, NM_031836.2, NM_031836.3, NM_001110333.1, NM_001110333.2, NM_001110334.1, NM_001110334.2, NM_001110335.1, NM_001287114.1, NM_001287110.1, NM_001287113.1, NM_001287112.1, NM_001287108.1, NM_001287107.1, NM_001287111.1, BC168708
UniProt ID P16612
Summary This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. provided by RefSeq, Nov 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Oct4-dependent FoxC1 activation improves the survival and neovascularization of mesenchymal stem cells under myocardial ischemia
Ji, Chen, Cui et al
Stem Cell Res Ther (2021) 12 (1), 483 DOI: 10.1186/s13287-021-02553-w
Cited by 12
AI Summary: In this study, OriGene products including the FoxC1 overexpression plasmid (RC211364) and Oct4 siRNA (SR307326) were used to manipulate gene expression in endothelial and mesenchymal stem cells, enabling the authors to demonstrate the critical role of the FoxC1/Oct4 axis in enhancing stem cell survival and neovascularization under ischemic conditions.
FigureFigureFigure
MicroRNA-185 inhibits cell proliferation and induces cell apoptosis by targeting VEGFA directly in von Hippel-Lindau-inactivated clear cell renal cell carcinoma
Ma, Shen, Li et al
Urol. Oncol. (2015)
Cited by 67
AI Summary: OriGene’s myc-DDK–tagged VEGFA plasmid was used in rescue experiments to restore VEGFA expression in VHL-inactivated A498 cells, helping to demonstrate that miR-185 inhibits cell proliferation and induces apoptosis by directly targeting VEGFA.
Snippet: 2.9. VEGFA rescue experiments. VHL-inactivated A498 cells were transfected with VEGFA small interfering RNA (siRNA) (GenePharma) or cotransfected with miR-185 mimics and myc-DDK–tagged VEGFA plasmid (OriGene Technologies, Inc., Rockville, MD). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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