Setd7 Rat shRNA Plasmid (Locus ID 689954)
SKU
TF708040
Setd7 - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 689954 |
|---|---|
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Setd7 - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 689954). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001109558, NM_001109558.1 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response
Jetton, Flores-Bringas, Leahy et al
J Biol Chem (2021) 297 (5), 101250 DOI: 10.1016/j.jbc.2021.101250
Jetton, Flores-Bringas, Leahy et al
J Biol Chem (2021) 297 (5), 101250 DOI: 10.1016/j.jbc.2021.101250
Cited by 15
AI Summary: OriGene's PPARγ shRNA and scrambled control shRNA were used to generate stable INS-1 β-cell lines with reduced PPARγ expression, enabling the authors to demonstrate that PPARγ directly regulates SetD7 and Pdx1 expression in pancreatic β-cells.
Snippet: Rγ. We next tested direct regulation of SetD7 by PPARγ in INS-1 cells with a constitutively KD of PPARγ. We established and characterized GFP-tagged stable constitutive expression of PPARγ shRNA (Origene) and scrambled control (scr) in INS-1 β-cells (Fig. 2Ai). We obtained an shRNA clone that reduced PPARγ protein expression to 0.37-fold and correspondingly reduced Pdx1 (0.6-fold) and SetD7
Showing 1-1 of 1 papers.
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