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Rap1a Rat shRNA Plasmid (Locus ID 295347)

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SKU
TF700679
Rap1a - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 295347
Synonyms RAP-1A; rap 1A
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Rap1a - Rat, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 295347). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001005765, NM_001005765.1, BC083813
UniProt ID P62836
Summary Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1
Alemayehu, Dragan, Pape et al
PLoS ONE (2013) 8 (2), e56174 DOI: 10.1371/journal.pone.0056174
Cited by 67
AI Summary: In this study, OriGene products including Rap1A shRNA (OriGene, Cat# TL313386) and IQGAP1 shRNA (OriGene, Cat# TL314845) were used to deplete Rap1A and IQGAP1 expression, respectively, enabling the authors to demonstrate the essential roles of these proteins in LPA-induced breast cancer cell migration and invasion.
FigureFigureFigure
Showing 1-1 of 1 papers.
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