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Ins1 Mouse shRNA Plasmid (Locus ID 16333)

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SKU
TF518973
Ins1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 16333
Synonyms Ins-1; Ins2-rs1
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ins1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 16333). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC098468, NM_008386, NM_008386.1, NM_008386.2, NM_008386.3, NM_008386.4, BC145868, BC145870
UniProt ID P01325
Summary This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. provided by RefSeq, Aug 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
Fu, Tian, Pratt et al
PLoS One (2009) 4 (5), e5679 DOI: 10.1371/journal.pone.0005679
Cited by 85
AI Summary: OriGene’s ZnT8 shRNA (rat) was used in this study to downregulate ZnT8 expression in INS-1 pancreatic beta cells, enabling the researchers to demonstrate that reduced ZnT8 levels lead to lower insulin content and impaired glucose-stimulated insulin secretion.
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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