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Itpr1 Mouse shRNA Plasmid (Locus ID 16438)

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SKU
TF517036
Itpr1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 16438
Synonyms D6Pas2; ENSMUSG00000072853; Gm10429; InsP3R; insP3R1; Ip3r; IP3R 1; IP3R1; Itpr-1; opt; P400
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Itpr1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 16438). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_010585, NM_010585.1, NM_010585.2, NM_010585.3, NM_010585.4, NM_010585.5, BC003271, BC068269, BC172648
UniProt ID P11881
Summary Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (PubMed:23542070). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism
Díaz-Vegas, Cordova, Valladares et al
Front Physiol (2018) 9, 791 DOI: 10.3389/fphys.2018.00791
AI Summary: OriGene contributed the shIP3R1-pRFP–C-RS plasmid (TF517036), which was used for genetic inhibition of IP3R1 to study its role in mitochondrial calcium signaling in skeletal muscle fibers.
Snippet: The following plasmids were used. pCMV-Cepia3mt (Invitrogen N° 58219), pCMV- RCamP 1.07 (RCamPs) (plasmid map is shown in Figure S6) and shIP3R1-pRFP –C-RS (Origene TF517036)
FigureFigureFigure
Showing 1-1 of 1 papers.
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