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Nfe2l2 Mouse shRNA Plasmid (Locus ID 18024)

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SKU
TF515053
Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 18024
Synonyms Nr; Nrf2
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Nfe2l2 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 18024). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC026943, NM_010902, NR_132727, NM_010902.1, NM_010902.2, NM_010902.3, NM_010902.4, BC003340, BC057948
UniProt ID Q60795
Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway
Gambhir
Drug Discov Ther (2016)
Cited by 13
AI Summary: OriGene's Nrf2 shRNA plasmid (cat no. TF515053) was used in this study to knock down Nrf2 in INT 407 cells, enabling the researchers to demonstrate that Nrf2 activation is essential for the protective effects of 1,4-naphthoquinone against radiation-induced gastrointestinal injury.
Snippet: Nrf2 shRNA plasmid (cat no. TF515053, Origene, Rockville, MD, USA) was used for knocking down Nrf2 in INT 407 cells. Transfection was performed using Neon Transfection System (Invitrogen, Carlsbad, CA, USA) following manufacturer`s protocol. ... Cite SaveSaving
Baicalein Exhibits Anti-inflammatory Effects via Inhibition of NF-κB Transactivation
Patwardhan, Sharma, Thoh et al
Biochem. Pharmacol. (2016)
Cited by 73
AI Summary: OriGene's Trx1 overexpression plasmid (TF515053) was used in this study to over-express thioredoxin 1 (Trx1) in EL4 cells, enabling the authors to investigate the role of thioredoxin in baicalein's anti-inflammatory mechanism.
Snippet: T4 polynucleotide kinase and kinase buffers were purchased from New England Biolabs (Ipswich, MA). Overexpression plasmid for Trx1 was purchased from Origene (Rockville MD, USA). ... TF515053, Origene) was used for over-expressing Trx1 in EL4 cells. ... Cite SaveSaving
Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells
Patwardhan, Checker, Sharma et al
PLoS ONE (2013) 8 (6), e65929 DOI: 10.1371/journal.pone.0065929
Cited by 29
AI Summary: OriGene products contributed to this study by providing shRNA plasmids targeting ERK (TF502598) and Nrf-2 (TF515053), which were used to investigate the roles of these proteins in radiation-induced cell death and radioresistance mechanisms.
Snippet: shRNA containing plasmids for ERK and Nrf-2 were purchased from Origene, Rockville, MD, USA. Thioredoxin activity kit was purchased from IMCO, Sweden. ... No. TF515053 for Nrf-2 and TF502598 for Erk Origene) were used in subsequent experiments.
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Showing 1-3 of 3 papers.
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