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Sox9 Mouse shRNA Plasmid (Locus ID 20682)

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SKU
TF511411
Sox9 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 20682
Synonyms 2010306G03Rik; AV220920; mKIAA4243
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Sox9 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 20682). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC023796, BC023808, BC023953, BC024958, BC034264, NM_011448, NM_011448.1, NM_011448.2, NM_011448.3, NM_011448.4, BC004064
UniProt ID Q04887
Summary Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development (PubMed:20940257, PubMed:28263186). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (PubMed:20940257).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Stem Cell Factor SOX9 Interacts with a Cell Death Regulator RIPK1 and Results in Escape of Cancer Stem Cell Death
Oh, Son, Rho et al
Cells (2022) 11 (3) DOI: 10.3390/cells11030363
Cited by 6
AI Summary: OriGene’s RIPK1 siRNA (SR305755) was used in this study to specifically silence RIPK1 expression, enabling the authors to investigate the functional interaction between SOX9 and RIPK1 in ovarian cancer stem cell death.
Snippet: X9 short hairpin RNAs (Sox9 shRNA) (SHCLNG-NM_000346) and Mission lentiviral packaging mix (SHP001) were purchased from Merk. RIPK1 small interfering RNAs (RIPK1 siRNA) (SR305755) were purchased from ORIGENE (Rockville, MD). SOX9 shRNA and RIPK1 siRNA sequences are listed in Supplementary Materials (Table S1). Cells numbering 2774 were lentivirally transduced using pLKO.1-Sox9 plasmid or pLKO.1-co
FigureFigureFigure
Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths
Wolock, Krishnan, Tenen et al
Cell Rep (2019) 28 (2), 302-311.e5 DOI: 10.1016/j.celrep.2019.06.031
AI Summary: OriGene products, specifically shRNA constructs targeting Nr4a3 (TF501493), Maff (TF501290), Dlx3 (TF500537), Creb3l3 (TF513785), and Mef2c (TF511428), were used in this study to perform targeted knockdowns of key transcription factors, enabling validation of differentiation pathways in bone marrow stromal cell populations.
Snippet: Osteogenic media STEMCELL Technologies Cat# 05504 Adipogenesis media STEMCELL Technologies Cat# 05503 Chondrocyte differentiation GIBCO Cat# A1007101 shRNA - TF501493 (Nr4a3) Origene Mouse, 4 unique 29-mer shRNA constructs in retroviral RFP vector shRNA-TF501290(Maff) Origene 4 unique shRNA shRNA - TF500537 (Dlx3) Origene 4 unique shRNA shRNA - TF513785;Osteogenic media STEMCELL Technologies Cat# 05504 Adipogenesis media STEMCELL Technologies Cat# 05503 Chondrocyte differentiation GIBCO Cat# A1007101 shRNA – TF501493 (Nr4a3) Origene Mouse, 4 unique 29-mer shRNA constructs in retroviral RFP vector shRNA - TF501290 (Maff) Origene 4 unique shRNA shRNA - TF500537 (Dlx3) Origene 4 unique shRNA shRNA - TF513785 (Creb3l3) Origene 4 unique shRNA shRNA - TF511428 (Mef2c) Origene 4 unique shRNA
SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma
Luanpitpong, Li, Manke et al
Oncogene (2015)
Cited by 124
AI Summary: In this study, the SOX9 expression plasmid from OriGene was used to transfect human lung cancer cells, enabling the authors to investigate the role of SOX9 in cancer stem cell regulation and metastasis.
Snippet: H460 and A549 cells were transfected with SNAI2 (Addgene, plasmid 31698), 48 SOX9 (Origene, Rockville, MD, USA) or GFP (Invitrogen, Carlsbad, MA, USA) plasmid by nucleofection using Nucleofector (Amexa Biosystems, Cologne, Germany), according to the ... Cite SaveSaving
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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