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Mmp14 Mouse shRNA Plasmid (Locus ID 17387)

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SKU
TF510301
Mmp14 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 17387
Synonyms AI325305; MMP-X1; MT-MMP-1; MT1-MM; MT1-MMP; sa; sabe
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mmp14 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 17387). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC076638, NM_008608, NM_008608.1, NM_008608.2, NM_008608.3, NM_008608.4
UniProt ID P53690
Summary This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. provided by RefSeq, Feb 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo
Ulasov, Borovjagin, Kaverina et al
Cancer Lett (2015) 365 (2), 240-50 DOI: 10.1016/j.canlet.2015.06.002
Cited by 15
AI Summary: In this study, OriGene’s MMP14 shRNA plasmid and MMP14 antibody were used to specifically silence and detect MMP14 expression, enabling the authors to demonstrate that targeting MMP14 with shRNA-armed adenoviruses suppresses glioma growth and angiogenesis both in vitro and in vivo.
Showing 1-1 of 1 papers.
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