Phactr4 Mouse shRNA Plasmid (Locus ID 100169)
Specifications
| Product Data | |
| Locus ID | 100169 |
|---|---|
| Synonyms | 3110001B12Rik; AI527228; AW495572; C330013F19Rik; mKIAA4120; N28169 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Phactr4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 100169). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | BC075672, BC096033, NM_001161797, NM_175306, NM_175306.1, NM_175306.2, NM_175306.3, NM_175306.4, NM_001161797.1, BC037059 |
| UniProt ID | Q501J7 |
| Summary | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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