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Trpm4 Mouse shRNA Plasmid (Locus ID 68667)

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SKU
TF504191
Trpm4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 68667
Synonyms 1110030C19Rik; AW047689; LTrpC-4; LTRPC4; TRPM4B
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Trpm4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 68667). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC096475, NM_175130, NM_175130.1, NM_175130.2, NM_175130.3, NM_175130.4, BC046472, BC046537, BC049165, BC049993, BC058632
UniProt ID Q7TN37
Summary Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:17188667, PubMed:29211714). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells (PubMed:18758465).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility
Cáceres, Ortiz, Recabarren et al
PLoS ONE (2015) 10 (6), e0130540 DOI: 10.1371/journal.pone.0130540
Cited by 65
AI Summary: OriGene contributed to this study by providing shRNA TRPM4, which was used to knock down TRPM4 expression and investigate its role in focal adhesion dynamics, cell migration, and contractility.
Snippet: TRPM4 activity was modulated by treating the cells with 9-phenanthrol (Sigma-Aldrich, St Louis, MO, USA), a TRPM4 inhibitor [18]. TRPM4 knockdown was performed by transfecting the cells with shRNAs against murine TRPM4 (shRNA TRPM4 ) (Origene, Rockville ... Cite SaveSaving
Showing 1-1 of 1 papers.
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