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Nr4a3 Mouse shRNA Plasmid (Locus ID 18124)

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SKU
TF501493
Nr4a3 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 18124
Synonyms AI573420; CHN; CSMF; M; MINOR; N; NO; NOR-1; Nor1; TEC
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Nr4a3 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 18124). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_015743, NM_015743.1, NM_015743.2, NM_015743.3, BC038520, BC068150, BC128307, BC128308, BC148436, BC156736
UniProt ID Q9QZB6
Summary This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Apr 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths
Wolock, Krishnan, Tenen et al
Cell Rep (2019) 28 (2), 302-311.e5 DOI: 10.1016/j.celrep.2019.06.031
AI Summary: OriGene products, specifically shRNA constructs targeting Nr4a3 (TF501493), Maff (TF501290), Dlx3 (TF500537), Creb3l3 (TF513785), and Mef2c (TF511428), were used in this study to perform targeted knockdowns of key transcription factors, enabling validation of differentiation pathways in bone marrow stromal cell populations.
Snippet: Osteogenic media STEMCELL Technologies Cat# 05504 Adipogenesis media STEMCELL Technologies Cat# 05503 Chondrocyte differentiation GIBCO Cat# A1007101 shRNA - TF501493 (Nr4a3) Origene Mouse, 4 unique 29-mer shRNA constructs in retroviral RFP vector shRNA-TF501290(Maff) Origene 4 unique shRNA shRNA - TF500537 (Dlx3) Origene 4 unique shRNA shRNA - TF513785;Osteogenic media STEMCELL Technologies Cat# 05504 Adipogenesis media STEMCELL Technologies Cat# 05503 Chondrocyte differentiation GIBCO Cat# A1007101 shRNA – TF501493 (Nr4a3) Origene Mouse, 4 unique 29-mer shRNA constructs in retroviral RFP vector shRNA - TF501290 (Maff) Origene 4 unique shRNA shRNA - TF500537 (Dlx3) Origene 4 unique shRNA shRNA - TF513785 (Creb3l3) Origene 4 unique shRNA shRNA - TF511428 (Mef2c) Origene 4 unique shRNA
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Segala, David, de Medina et al
Nat Commun (2017) 8 (1), 1903 DOI: 10.1038/s41467-017-01948-9
AI Summary: OriGene’s 29 mer shRNA constructs in pRS retroviral vectors targeting Nur77 and NOR1 were used for gene knockdown experiments to investigate the role of these genes in Dendrogenin A-induced lethal autophagy in cancer cells.
Snippet: For the KD of Nur77 and NOR1 in KG1, 29 mer shRNA constructs in pRS retroviral vectors targeting Nur77 and NOR1 were purchased from Origene
FigureFigureFigure
A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans
Heard, Maina, Morehead et al
Genesis (2010) 48 (8), 485-91 DOI: 10.1002/dvg.20646
Cited by 10
AI Summary: OriGene’s TrueORF cDNA clones were used in this study to express and analyze NHR-6 function, enabling the authors to investigate the DNA-binding and transcriptional activity of the NR4A nuclear receptor in Caenorhabditis elegans.
FigureFigure
Showing 1-3 of 3 papers.
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