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Klf4 Mouse shRNA Plasmid (Locus ID 16600)

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SKU
TF501193
Klf4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 16600
Synonyms EZF; Gklf; Zie
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Klf4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 16600). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC010301, NM_010637, NM_010637.1, NM_010637.2, NM_010637.3, BC091737
UniProt ID Q60793
Summary Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4
Dong, Xie, Xu
Oncol Lett (2019) 17 (3), 3241-3246 DOI: 10.3892/ol.2019.10001
AI Summary: OriGene’s KLF4 plasmid was used in this study to overexpress KLF4 in colorectal cancer cells, enabling the authors to demonstrate that KLF4 overexpression could counteract the tumor-suppressive effects of miR-7-5p.
Snippet: …KLF4 small interfering (si)RNA (si-KLF4;5′-CCAGCCAGAAAGCACUACAAU-3′) and NC siRNA (NC-siR;5′-AUGCAAUACCGCAGAACACCA-3′) were purchased from Guangzhou RiboBio Co., Ltd. … The KLF4 plasmid, obtained from OriGene Technologies, Inc. … Transfection was conducted using Lipofectamine ٢٠٠٠ (Invitrogen;Thermo Fisher Scientific, Inc.) with ٥٠ nM miRNA, 50 nM siRNA, or 1 µg KLF4 plasmid, according to the manufacturer's protocol. …
FigureFigureFigure
Showing 1-1 of 1 papers.
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