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Il10 Mouse shRNA Plasmid (Locus ID 16153)

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SKU
TF501065
Il10 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 16153
Synonyms CSIF; If2a; IL-; Il-10
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Il10 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 16153). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC120612, NM_010548, NM_010548.1, NM_010548.2, BC137844
UniProt ID P18893
Summary This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis
Biagioli, Carino, Cipriani et al
J. Immunol. (2017)
AI Summary: OriGene products—specifically the IL-10 mouse shRNA plasmid (pRFP-C-RS) and GPBAR1 mouse shRNA plasmid (pGFP-V-RS)—were used in this study to suppress IL-10 and GPBAR1 expression, enabling the authors to investigate the functional roles of these genes in macrophage phenotype regulation and colitis.
Snippet: For IL-10 RNA silencing, an IL-10 mouse short hairpin RNA plasmid (pRFP-C-RS) and a GPBAR1 mouse short hairpin RNA plasmid (pGFP-V- RS) were purchased from OriGene Technologies and were used to suppress IL-10 and GPBAR1 expression.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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