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Cxcr4 Mouse shRNA Plasmid (Locus ID 12767)

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SKU
TF500383
Cxcr4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 12767
Synonyms b2b220Clo; CD184; Cmkar4; LESTR; PB-CKR; PBSF/SDF-1; Sdf1r
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Cxcr4 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 12767). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC031665, BC098322, NM_009911, NM_009911.1, NM_009911.2, NM_009911.3, NM_001356509
UniProt ID P70658
Summary Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells
Ieranò, D'Alterio, Giarra et al
Cell Death Dis (2019) 10 (8), 562 DOI: 10.1038/s41419-019-1796-6
AI Summary: OriGene products pCMV6-AC-GFP Vector (TrueORF clone) and pCMV6-AC-h-CXCR4-GFP Vector (TrueORF clone) were used to transfect B16 cells, enabling the study of CXCR4-expressing melanoma cell migration and trapping by the CXCL12-loaded dermal filler in this research.
Snippet: reducing metastases. Materials and methods. Cell culture. B16 cells were transfected with 5 µg of pCMV6-AC-GFP Vector (TrueORF clone;Origene) or with 5 µg of pCMV6-AC-h-CXCR4-GFP Vector (TrueORF clone;Origene). B16
FigureFigureFigure
Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment
Arai, Choi, Corsino et al
Mol Ther (2018) 26 (5), 1181-1197 DOI: 10.1016/j.ymthe.2018.03.003
Cited by 62
AI Summary: In this study, OriGene’s pBMN CXCR4 (OriGene, MC210630) plasmid was used to transduce c-kit CAR-T cells, enhancing their migration to bone marrow and enabling effective stem cell engraftment in recipient mice.
Showing 1-2 of 2 papers.
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