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MARK1 Human shRNA Plasmid Kit (Locus ID 4139)

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TF320412
MARK1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4139
Synonyms MARK; Par-1c; Par1c
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Format Retroviral plasmids
Components MARK1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 4139). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001286124, NM_001286126, NM_001286128, NM_001286129, NM_018650, NM_018650.1, NM_018650.2, NM_018650.3, NM_018650.4, NM_001286129.1, NM_001286128.1, NM_001286126.1, NM_001286124.1, BC114478, BC068608, BC113869, NM_001286129.2, NM_018650.5, NM_001286128.2
UniProt ID Q9P0L2
Summary Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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