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BID Human shRNA Plasmid Kit (Locus ID 637)

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SKU
TF314477
BID - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 637
Synonyms FP497
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BID - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 637). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001196, NM_001244567, NM_001244569, NM_001244570, NM_001244572, NM_197966, NM_197967, NM_001196.1, NM_001196.2, NM_001196.3, NM_197966.1, NM_197966.2, NM_197967.1, NM_197967.2, NM_001244569.1, NM_001244570.1, NM_001244572.1, NM_001244567.1, BC036364, BC036364.1, BC005884, BC009197, BC022072, BC033634, BM561391, BM842561
UniProt ID P55957
Summary This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. provided by RefSeq, Aug 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid
Luanpitpong, Chanthra, Janan et al
Mol. Cancer Ther. (2017)
AI Summary: OriGene’s retroviral plasmids carrying short hairpin RNA (shRNA) against human BID were used in this study to knock down BID expression and investigate its role in apoptosis sensitization and bortezomib resistance in mantle cell lymphoma.
Snippet: Retroviral plasmids carrying short hairpin (sh) RNA sequence against human BID were obtained from Origene (Rockville, MD) and shBID retroviral production was performed using Platinum-A packaging cells (Cell Biolabs, Inc, San Diego, CA). Cells were incubated
Showing 1-1 of 1 papers.
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