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DNMT1 Human shRNA Plasmid Kit (Locus ID 1786)

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SKU
TF313404
DNMT1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 1786
Synonyms ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components DNMT1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 1786). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001130823, NM_001318730, NM_001318731, NM_001379, NM_001379.1, NM_001379.2, NM_001379.3, NM_001130823.1, NM_001130823.2, BC092517, BC126227, BC144093, NM_001130823.3
UniProt ID P26358
Summary This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O(6)-methylguanine DNA-methyltransferase, in breast cancer cells
Chen, Zhang, Zhang
Sci Rep (2015) 5, 14723 DOI: 10.1038/srep14723
Cited by 22
AI Summary: OriGene’s Trilencer-27 Human siRNA kits targeting ERp29, MGMT, and DNMT1 were used in this study to selectively knock down these genes and investigate their roles in radioresistance and DNA repair in breast cancer cells.
Snippet: ERp29 Trilencer-27 Human siRNA, MGMT Trilencer-27 Human siRNA and DNMT1 Trilencer-27 Human siRNA kits include three Dicer-Substrate 27-mer duplexes for each gene and were purchased from Origene (Rockville, MD). ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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