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IGFBP3 Human shRNA Plasmid Kit (Locus ID 3486)

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SKU
TF312217
IGFBP3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 3486
Synonyms BP-53; IBP3
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IGFBP3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 3486). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_000598, NM_001013398, NM_000598.1, NM_000598.2, NM_000598.3, NM_000598.4, NM_001013398.1, BC064987, BC064987.1, BC000013, BC018962, NM_000598.5
UniProt ID P17936
Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma
Thota, Arimappamagan, Kandavel et al
J. Neurosurg. (2014)
AI Summary: OriGene products, specifically the 29-mer short hairpin (sh)RNA cassette directed against IGFBP-3 and the scrambled shRNA (pRFP-C-RS shRNA vector), were used to knock down IGFBP-3 expression in glioma cells, enabling the study of IGFBP-3’s role in regulating STAT-1 and its impact on tumor cell behavior and patient prognosis.
Snippet: dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and puromycin, from Sigma-Aldrich;dimethyl sulfoxide, from Merck;29-mer short hairpin (sh)RNA cassette directed against IGFBP-3 and scrambled shRNA (pRFP-C-RS shRNA vector), from OriGene Technologies ... Cite SaveSaving
Showing 1-1 of 1 papers.
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