VEGFA Human shRNA Plasmid Kit (Locus ID 7422)
SKU
TF308426
VEGFA - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 7422 |
|---|---|
| Synonyms | MVCD1; VEGF; VPF |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | VEGFA - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 7422). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001025366, NM_001025367, NM_001025368, NM_001025369, NM_001025370, NM_001033756, NM_001171622, NM_001171623, NM_001171624, NM_001171625, NM_001171626, NM_001171627, NM_001171628, NM_001171629, NM_001171630, NM_001204384, NM_001204385, NM_001287044, NM_003376, NM_001317010, NM_001033756.1, NM_001033756.2, NM_001025367.1, NM_001025367.2, NM_001025370.1, NM_001025370.2, NM_001025366.1, NM_001025366.2, NM_001025368.1, NM_001025368.2, NM_003376.1, NM_003376.2, NM_003376.3, NM_003376.4, NM_003376.5, NM_001025369.1, NM_001025369.2, NM_001171630.1, NM_001171628.1, NM_001171627.1, NM_001171626.1, NM_001171629.1, NM_001171625.1, NM_001171624.1, NM_001171623.1, NM_001171622.1, NM_001204384.1, NM_001204385.1, NM_001287044.1, BC011177, BC019867, BC058855, BC065522, BC172307, BM661679, NM_001025369.3, NM_001033756.3, NM_001204385.2, NM_001025367.3, NM_001287044.2, NM_001171622.2, NM_003376.6, NM_001025368.3, NM_001025370.3, NM_001025366.3 |
| UniProt ID | P15692 |
| Summary | This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. provided by RefSeq, Jun 2020 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.