OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

VEGFA Human shRNA Plasmid Kit (Locus ID 7422)

Be the first to review this product
SKU
TF308426
VEGFA - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

Frequently Bought Together (2)

TA500289 VEGFA (VEGF) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3) 100 ul
$447.00
TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "VEGFA or NM_001025366"

Specifications
Specifications
Product Data
Locus ID 7422
Synonyms MVCD1; VEGF; VPF
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components VEGFA - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 7422). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001025366, NM_001025367, NM_001025368, NM_001025369, NM_001025370, NM_001033756, NM_001171622, NM_001171623, NM_001171624, NM_001171625, NM_001171626, NM_001171627, NM_001171628, NM_001171629, NM_001171630, NM_001204384, NM_001204385, NM_001287044, NM_003376, NM_001317010, NM_001033756.1, NM_001033756.2, NM_001025367.1, NM_001025367.2, NM_001025370.1, NM_001025370.2, NM_001025366.1, NM_001025366.2, NM_001025368.1, NM_001025368.2, NM_003376.1, NM_003376.2, NM_003376.3, NM_003376.4, NM_003376.5, NM_001025369.1, NM_001025369.2, NM_001171630.1, NM_001171628.1, NM_001171627.1, NM_001171626.1, NM_001171629.1, NM_001171625.1, NM_001171624.1, NM_001171623.1, NM_001171622.1, NM_001204384.1, NM_001204385.1, NM_001287044.1, BC011177, BC019867, BC058855, BC065522, BC172307, BM661679, NM_001025369.3, NM_001033756.3, NM_001204385.2, NM_001025367.3, NM_001287044.2, NM_001171622.2, NM_003376.6, NM_001025368.3, NM_001025370.3, NM_001025366.3
UniProt ID P15692
Summary This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. provided by RefSeq, Jun 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products