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WRN Human shRNA Plasmid Kit (Locus ID 7486)

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SKU
TF308355
WRN - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 7486
Synonyms RECQ3; RECQL2; RECQL3
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components WRN - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 7486). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_000553, NM_000553.1, NM_000553.2, NM_000553.3, NM_000553.4
UniProt ID Q14191
Summary This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress
Basile, Leuzzi, Pichierri et al
Nucleic Acids Res. (2014)
Cited by 42
AI Summary: OriGene's shRNA against WRN was used to generate WRN-deficient HEK293T cells, enabling the study of WRN's roles in checkpoint activation and genome stability under mild replication stress.
Snippet: Cell cultures. HEK293T cells were obtained from American Type Culture Collection (VA, USA). HEK293T cells proficient and deficient for WRN were generated by stably expressing, respectively, a scrambled shRNA (shCTRL) or shRNA against WRN (shWRN) (OriGene ... Cite SaveSaving
Showing 1-1 of 1 papers.
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