PI 3 Kinase catalytic subunit alpha (PIK3CA) Human shRNA Lentiviral Particle (Locus ID 5290)
SKU
TL310428V
PIK3CA - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
$1,731.00
3 Weeks*
Specifications
| Product Data | |
| Locus ID | 5290 |
|---|---|
| Synonyms | CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral particles |
| Components | PIK3CA - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml. |
| RefSeq | NM_006218, NM_006218.1, NM_006218.2, NM_006218.3, BC113601, BC113603, NM_006218.4 |
| UniProt ID | P42336 |
| Summary | Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. provided by RefSeq, Apr 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
| Storage | Store at -80°C |
| Shipping | Dry Ice |
Reviews
Documents
Resources
Citations
Multi-Kinase Inhibitor with Anti-p38γ Activity in Cutaneous T-Cell Lymphoma
Zhang, Nam, Wu et al
J Invest Dermatol (2018) 138 (11), 2377-2387 DOI: 10.1016/j.jid.2018.04.030
Zhang, Nam, Wu et al
J Invest Dermatol (2018) 138 (11), 2377-2387 DOI: 10.1016/j.jid.2018.04.030
Cited by 25
AI Summary: In this study, OriGene’s p38γ shRNA (TL313307) and p38γ cDNA (RC208507) were used to manipulate p38γ expression in CTCL cells, enabling the authors to demonstrate the critical role of p38γ in CTCL cell viability and to validate the effects of the multi-kinase inhibitor PIK75.
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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