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MIRLET7c Human MicroRNA Expression Plasmid (MI0000064)

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SKU
SC400005
Expression plasmid for human microRNA LET7c
  $424.00
In Stock*

Frequently Bought Together (1)

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5 x 200 ul
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Specifications
Specifications
Product Data
Species Human
Vector pCMV-MIR
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequences
Precursor: GCAUCCGGGUUGAGGUAGUAGGUUGUAUGGUUUAGAGUUACACCCUGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUGGAGC:
Mature Sequence: UGAGGUAGUAGGUUGUAUGGUU:
Full Insert
>MI0000064 GTTTTTATTGAGCCTATTTCTCCTGAAAAAATGAGGCTGAATGCAATTGACTTTTACTATTAATTGCGAC
TAGAACTATGGCAGGTTAGATGGTCAGAAGACATTTTACGTGACCTATGCTGGAAACCCAAGTGTTTAGG
TTAGTCCTATGAGAAACAGTTAGCAGCAAAGTTTACTGGTAAAATGTTAGAATATTATATCTATATCCTT
GCCAAGCCCTTAGGTGTATGGCTGCCATATTTGGAGGAGCTGACTGAAGATATGATAAGGAGTTTGAAGC
AACATTGGAAGCTGTGTGCATCCGGGTTGAGGTAGTAGGTTGTATGGTTTAGAGTTACACCCTGGGAGTT
AACTGTACAACCTTCTAGCTTTCCTTGGAGCACACTTGAGCCGTCGAGGAATTCTTCATCACTTTAACCT
GATTGAGCCAATTTGTGTGCAAGAAGGTAATGTGTCATGAGTATCTTGGATCATTGATTTGGGCCTTTAT
TACATTAAAATGATCATTTCAGCCCTATTAGATTATTCCATTTGTATCTGCTTATGAACAATGTCAAAAT
GGTATTTCTAATGGGTTGTCACTCCATGTTCAAACATTTTAAGAAAATTGTAGGTAGTGACTTAAATTGC
ATTAATATTAAAGCTTTTTATCATCTATAGATTAACAAAATTCAGACC
Components 1 x 10 ug vial miRNA plasmid lyophilized in a 2-D bar-coded Matrix tube
Also Contains Both mature and minor (star) miRNA can be over expressed from the construct.
OTI Disclaimer All miRNA clones were sequenced to ensure that the pre-mir sequences match reference sequence in miRBase. The flanking sequence of a miRNA clone may differ from the NCBI reference with respect to biological polymorphisms. This should not affect the function of the mature miRNA.
Shipping Ambient
Reference Data
RefSeq MI0000064
Synonyms LET7C let-7c MIRNLET7C hsa-let-7c
Locus ID 406885
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Documents
Resources

file-alt Citations

Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targetingIGF1RandHMGA2
Hou, Ishinaga, Midorikawa et al
Oncotarget (2018) 9 (10), 8927-8940 DOI: 10.18632/oncotarget.23826
Snippet: miRNA plasmid transfection. The let-7c expression vector pCMV-MIR-let-7c and the pCMV-MIR vector were obtained from Origene (Rockville, MD, USA) Three vectors (Origene), namely, pCMV6-control, pCMV6-IGF1R, and pCMV6-HMGA2, were used for the rescue
FigureFigureFigure
A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells
Yeh, Huang, Rao et al
Carcinogenesis (2013)
Cited by 81
AI Summary: OriGene's miR-let-7c precursor (SC400005) was used to increase miR-let-7c expression in lung cancer cells, helping to investigate the role of this microRNA in antrocin-induced apoptosis and JAK2/STAT3 pathway inhibition.
Snippet: A TRIzol RNA isolation kit was obtained from Life Technologies (Rockville, MD), and primers for reverse transcription–polymerase chain reaction (RT–PCR), deoxynucleoside ... The miR-let-7c expression in cells was increased by transfection with precursor (SC400005, Origene).
Showing 1-2 of 2 papers.
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