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LAMTOR1 (NM_017907) Human Recombinant Protein

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SKU
TP762012
Purified recombinant protein of Human late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 (LAMTOR1),Gly2–Pro161, with N-terminal His-PDCD1(Pro21-Val170) tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region(Gly2–Pro161) of LAMTOR1
Tag N-His PDCD1(Pro21-Val170)
Predicted MW 34.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_060377
Locus ID 55004
UniProt ID Q6IAA8
Cytogenetics 11q13.4
RefSeq Size 1198
RefSeq ORF 483
Synonyms C11orf59; p18; p27RF-Rho; PDRO; Ragulator1
Summary As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.UniProtKB/Swiss-Prot Function
Protein Categories Growth Factors, Intracellular Proteins
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Other "LAMTOR1" proteins (2)
SKU Description Size Price
LC413453 Lyophilized LAMTOR1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY413453 Transient overexpression lysate of chromosome 11 open reading frame 59 (C11orf59) (as WB positive control) 100 ug
$436.00

file-alt Citations

Haloperidol inhibits inflammasome activation via LAMTOR1 and reduces the risk of arthritides
Ambati, Yerramothu, Konduri et al
medRxiv (2023)
Cited by 1
Snippet: For in vitro binding and competition assays, recombinant His-PDCD1-tagged human LAMTOR1 protein (TP762012, OriGene) was precleared using streptavidin magnetic beads (88816, Thermo Fisher) to remove nonspecific binding and then incubated
Showing 1-1 of 1 papers.
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