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APC (NM_001127511) Human Recombinant Protein

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SKU
TP761993
Purified recombinant protein of Human adenomatous polyposis coli (APC), transcript variant 1,Glu955-Leu1382, with N-terminal His tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region(Glu955-Leu1382)of APC
Tag N-His
Predicted MW 47.7 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001120983
Locus ID 324
UniProt ID P25054
Cytogenetics 5q22.2
RefSeq ORF 8529
Synonyms BTPS2; DESMD; DP2; DP2.5; DP3; GS; PPP1R46
Summary This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. provided by RefSeq, Dec 2019
Protein Categories Cancer: Brain and CNS, Cancer: Gastrointestinal, Cytokines, Endocrine and metabolic diseases, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway
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Other "APC" proteins (2)
SKU Description Size Price
LC426808 Lyophilized APC HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY426808 Transient overexpression lysate of adenomatous polyposis coli (APC), transcript variant 1 (as WB positive control) 100 ug
$665.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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