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EHD3 (NM_014600) Human Recombinant Protein

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SKU
TP761227
Purified recombinant protein of Human EH-domain containing 3 (EHD3), full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length EHD3
Tag N-His
Predicted MW 60.7 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_055415
Locus ID 30845
UniProt ID Q9NZN3
Cytogenetics 2p23.1
RefSeq Size 3583
RefSeq ORF 1605
Synonyms PAST3
Summary ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250).UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
Protein Pathways Endocytosis
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Other "EHD3" proteins (4)
SKU Description Size Price
PH314168 EHD3 MS Standard C13 and N15-labeled recombinant protein (NP_055415) 10 ug
$3,360.00
LC402352 Lyophilized EHD3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402352 Transient overexpression lysate of EH-domain containing 3 (EHD3) (as WB positive control) 100 ug
$665.00
TP314168 Recombinant protein of human EH-domain containing 3 (EHD3), 20 µg 20 ug
$867.00

file-alt Citations

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome
Miyamoto, Hosoba, Itabashi et al
EMBO J. (2020)
Cited by 49
AI Summary: OriGene products 6×His‐EHD3 (TP761227) and 6×His‐Rabin8 (TP760069) were used in in vitro binding assays to investigate protein interactions involved in peroxisome-mediated cholesterol transport to ciliary membranes in Zellweger syndrome.
Snippet: GST (0.2 μg, Abcam: ab81793) or GST fused to PEX14 proteins (1 μg, Abnova: H00005195‐P01) was loaded to glutathione‐Sepharose beads (GE Healthcare) and then incubated with 6×His‐EHD3 (1 μg, ORIGENE: TP761227), 6×His‐Rabin8 (1 μg, ORIGENE: TP760069), or 6×His‐Rab10 (1 μg, NOVUS: NBP2‐23392). …
Showing 1-1 of 1 papers.
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