COQ6 (NM_182476) Human Recombinant Protein
Purified recombinant protein of Human coenzyme Q6 homolog, monooxygenase (S. cerevisiae) (COQ6), nuclear gene encoding mitochondrial protein, transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug
Specifications
Product Data | |
Description | Purified recombinant protein of Human coenzyme Q6 homolog, monooxygenase (S. cerevisiae) (COQ6), nuclear gene encoding mitochondrial protein, transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence | A DNA sequence encoding human full-length COQ6 |
Tag | N-His |
Predicted MW | 50.7 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_872282 |
Locus ID | 51004 |
Refseq Size | 1615 |
Cytogenetics | 14q24.3 |
Refseq ORF | 1404 |
Synonyms | CGI-10; CGI10; COQ10D6 |
Summary | The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012] |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, Ubiquinone and other terpenoid-quinone biosynthesis |
Documents
FAQs |
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Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC405540 | COQ6 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LC405541 | COQ6 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LY405540 | Transient overexpression lysate of coenzyme Q6 homolog, monooxygenase (S. cerevisiae) (COQ6), nuclear gene encoding mitochondrial protein, transcript variant 1 |
USD 360.00 |
|
LY405541 | Transient overexpression lysate of coenzyme Q6 homolog, monooxygenase (S. cerevisiae) (COQ6), nuclear gene encoding mitochondrial protein, transcript variant 2 |
USD 360.00 |
USD 360.00