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GTP cyclohydrolase 1 (GCH1) (NM_001024024) Human Recombinant Protein

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SKU
TP760518
Purified recombinant protein of Human GTP cyclohydrolase 1 (GCH1), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length GCH1
Tag N-His
Predicted MW 27.7 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001019195
Locus ID 2643
UniProt ID P30793
Cytogenetics 14q22.2
RefSeq Size 1995
RefSeq ORF 750
Synonyms DYT5; DYT5a; DYT14; GCH; GTP-CH-1; GTPCH1; HPABH4B
Summary This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. provided by RefSeq, Jul 2008
Protein Categories Intracellular Proteins, Nervous system Diseases
Protein Families Druggable Genome
Protein Pathways Folate biosynthesis, Metabolic pathways
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Other "GTP cyclohydrolase 1" proteins (5)
SKU Description Size Price
LC400058 Lyophilized GCH1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC422611 Lyophilized GCH1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400058 Transient overexpression lysate of GTP cyclohydrolase 1 (GCH1), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY422611 Transient overexpression lysate of GTP cyclohydrolase 1 (GCH1), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP760308 Recombinant protein of human GTP cyclohydrolase 1 (GCH1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug 50 ug
$270.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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