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REA (PHB2) (NM_001144831) Human Recombinant Protein

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SKU
TP760501
Purified recombinant protein of Human prohibitin 2 (PHB2), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

TA308685 Rabbit Polyclonal antibody to Prohibitin 2 (prohibitin 2)
100 ul
$665.00

Other products for "REA or NM_001144831"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length PHB2
Tag N-His
Predicted MW 33.1 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001138303
Locus ID 11331
UniProt ID Q99623
Cytogenetics 12p13.31
RefSeq Size 1457
RefSeq ORF 897
Synonyms BAP; Bap37; BCAP37; hBAP; p22; PNAS-141; REA
Summary Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, Transcription Factors
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Documents
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Other "REA" proteins (5)
SKU Description Size Price
LC402126 Lyophilized PHB2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC428526 Lyophilized PHB2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402126 Transient overexpression lysate of prohibitin 2 (PHB2), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY428526 Transient overexpression lysate of prohibitin 2 (PHB2), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP761198 Purified recombinant protein of Human prohibitin 2 (PHB2), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug 50 ug
$270.00

file-alt Citations

Caffeic acid suppresses cyclin D1 expression by directly binding to ribosomal protein S5 in colorectal cancer cells
Watanabe, Boku, Sukeno et al
Sci Rep (2026)
Cited by 1
AI Summary: OriGene's purified recombinant human PHB2 protein (catalog number TP760501) was used in this study to investigate the molecular mechanisms by which caffeic acid suppresses cyclin D1 expression in colorectal cancer cells.
Snippet: Purified recombinant human PHB2 (TP760501) was obtained from OriGene (Rockville, MD, USA). Purified recombinant human RPS5 (ab137146) was obtained from Abcam (Cambridge, UK). Primary antibodies used in the experiments include
Apolipoproteins L1 and L3 Control Mitochondrial Membrane Dynamics
Lecordier, Heo, Graversen et al
Cell Rep (2023) 42 (12), 113528 DOI: 10.1016/j.celrep.2023.113528
Cited by 26
AI Summary: OriGene products contributed to this study by providing recombinant PHB2 protein (Cat. TP760501) and the PHB2 plasmid (Cat. MR218376), which were used to investigate the interactions of apolipoproteins L1 and L3 with mitophagy-related proteins and their role in mitochondrial membrane dynamics.
Snippet: zureau et al.11 N/A Reccombinant NCS1 L89K Uzureau et al.11 N/A Recombinant Calneuron-1 Novus Biologicals NBP1-50858 Recombinant Calneuron-1 Prospec pro-279 Recombinant PHB2 Origene TP760501 Recombinant VAMP8 Abnova 8673-P01 Recombinant VAMP8 Novus Biologicals NBC1-18348 Recombinant VAMP8 Heo et al.132 N/A Recombinant sVAMP8 Heo et al.132 N/A;- pro-279);PHB2 (Origene Cat. TP760501);VAMP8 (Abnova Cat. 8673-P01 and PHB2 was amplified from Origene plasmid Cat. MR218376. …
Sensitive electrochemical immunosensor to detect prohibitin 2, a potential blood cancer biomarker
Yun, Lee, Seo et al
Talanta (2021) 238 (Pt 2), 123053 DOI: 10.1016/j.talanta.2021.123053
Cited by 15
AI Summary: OriGene’s PHB2 protein (catalog number TP760501) was used as the target antigen in the immunosensor development, enabling the researchers to evaluate the sensor’s ability to detect prohibitin 2 for blood cancer diagnostics.
Snippet: PHB2 (TP760501, OriGene Tech, Rockville, MD, USA) was bound to the surface-immobilized anti-PHB2 cAbs in a humid chamber at 37 °C for 1 h (step d)
Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2
Watanabe, Yamada, Kurumida et al
Cancers (Basel) (2021) 13 (5) DOI: 10.3390/cancers13050982
Cited by 7
AI Summary: OriGene products—purified recombinant human ANT2 (catalog No: TP308949) and PHB2 (catalog No: TP760501)—were used in this study to investigate and confirm the direct binding of rabdosianone I to its protein targets, supporting the discovery of its mechanism in suppressing thymidylate synthase expression.
Snippet: to make stock solutions. Purified recombinant human ANT2 (Homo sapiens solute carrier family 25, member 5, catalog No: TP308949) and PHB2 (Human prohibitin 2, catalog No: TP760501) were obtained from OriGene (Rockville, MD, USA). 4.2. Cell Lines and Culture The human colorectal cancer cell lines HT-29, HCT116, and HCT-15 were obtained as NCI-60 cell lines from the NCI Developmental Therapeutics P
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Showing 1-4 of 4 papers.
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