RIP(RIPK1) (NM_003804) Human Recombinant Protein

CAT#: TP760433

Purified recombinant protein of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug


 Product Datasheet for 'TP760433'

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USD 205.00


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    • 50 ug


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Specifications

Product Data
Description Purified recombinant protein of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding human full-length RIPK1
Tag N-His
Predicted MW 75.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_003795
Locus ID 8737
Refseq Size 3864
Cytogenetics 6p25.2
Refseq ORF 2013
Synonyms RIP; RIP-1; RIP1
Summary This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]
Protein Families Protein Kinase, Druggable Genome
Protein Pathways Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway

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