Cardiac Troponin T (TNNT2) (NM_000364) Human Recombinant Protein

SKU TP750172

Purified recombinant protein of Human troponin T type 2 (cardiac) (TNNT2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50 ug

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the full-length of TNNT2
• Tag: N-HIS
• Predicted MW: 35.4KDa
• Concentration: >0.05 µg/µL as determined by spectrophotometrically（A280） method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from 0.01 M HCl, reconstitute with Tris/urea buffer (20 mM Tris, pH 7.5, 7 M urea, 5 mM EDTA, 15 mM β-mercaptoethanol)
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -20°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Ambient

Reference Data

• RefSeq: NP_000355
• Locus ID: 7139
• UniProt ID: P45379
• Cytogenetics: 1q32.1
• RefSeq Size: 1153
• RefSeq ORF: 885
• Synonyms: CMD1D; CMH2; CMPD2; cTnT; LVNC6; RCM3; TnTC
• Summary: The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome
• Protein Pathways: Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)