TNFRSF18 Human Recombinant Protein

SKU
TP723942
Recombinant human GITR protein with C-terminal mouse Fc and 6×His tag
  $770.00
4 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
GITR(Gln26-Pro162) mFc(Pro99-Lys330) 6×His
Tag C-Mouse Fc and 6×His Tag
Predicted MW The protein has a predicted molecular mass of 50-52 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Preparation Affinity purification
Recommended Dilution Flow Cyt
Storage Store the lyophilized protein at -20°C.
After reconstitution, store the protein at -80°C for 12 months.
Avoid repeated freezing and thawing.
Stability 12 months from date of despatch
Shipping Ambient
Reference Data
Locus ID 8784
UniProt ID Q9Y5U5
Synonyms AITR;GITR;TNFRSF18;CD357
Summary This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Protein Categories CD Markers, Membrane Proteins, Secreated Proteins
Protein Families Flow Cyt
Protein Pathways Cytokine-cytokine receptor interaction
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Other "TNFRSF18" proteins (7)
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LY407757 Transient overexpression lysate of tumor necrosis factor receptor superfamily, member 18 (TNFRSF18), transcript variant 2 (as WB positive control) 100 ug
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LY418153 Transient overexpression lysate of tumor necrosis factor receptor superfamily, member 18 (TNFRSF18), transcript variant 1 (as WB positive control) 100 ug
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TP319997 Recombinant protein of human tumor necrosis factor receptor superfamily, member 18 (TNFRSF18), transcript variant 1, 20 µg 20 ug
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TP723941 Recombinant human GITR protein with C-terminal human Fc and 6×His tag 100 ug
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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