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Timp1 (NM_011593) Mouse Recombinant Protein

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SKU
TP723887
Purified recombinant protein of Mouse tissue inhibitor of metalloproteinase 1 (Timp1), transcript variant 2
Size:
10 ug
  $465.00
2 Weeks*
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Mouse TIMP-1, the region of Cys27-Arg205, from gene Accession# NM_011593
Tag C-His
Predicted MW 22 kDa
Concentration lot specific
Purity >90%, as determined by Coomassie stained SDS-PAGE.
Buffer 20 mM Tris, 150 mM NaCl, pH 8.0
Bioactivity Mouse TIMP-1 inhibits the activity of activated mouse MMP-9 (100 ng/mL). The IC50 = 90 ng/mL.
Endotoxin Less than 1.0 EU per µg of protein as determine by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_035723
Locus ID 21857
UniProt ID P12032
Cytogenetics X 16.38 cM
RefSeq Size 902
RefSeq ORF 615
Synonyms Clgi; EPA; Timp; TIMP-1; TPA-S1
Summary Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.UniProtKB/Swiss-Prot Function
Protein Categories Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins
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Documents
Resources

file-alt Citations

Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha
Hikita, Tanaka, Yamane et al
Biochem Cell Biol (2009) 87 (4), 581-93 DOI: 10.1139/o09-015
Cited by 56
AI Summary: OriGene products, specifically the siRNAs for ADAM10 (SR300019) and ADAM17 (SR300020), were used in RNA interference experiments to elucidate the roles of these proteases in the shedding of TNF-alpha in various cell types.
Showing 1-1 of 1 papers.
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