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PCSK9 (NM_174936) Human Recombinant Protein

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SKU
TP723879
Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9)
Size:
10 ug
  $465.00
2 Weeks*
Bulk/Customize

Other products for "PCSK9 or NM_174936"

Specifications
Specifications
Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Protein Sequence
Human PCSK9, the region of Arg29-Gln692, from gene Accession# NM_174936
Tag C-His
Predicted MW 73 kDa
Concentration lot specific
Purity >90%, as determined by Coomassie stained SDS-PAGE.
Buffer 25 mM sodium Acetate, 150 mM NaCl, pH 5.0
Bioactivity When recombinant human LDLR is immobilized at 1 µg/mL, recombinant human PCSK9 binds with EC50 of 0.04 - 0.2 µg/mL in a functional ELISA.
Endotoxin Less than 1 EU per µg protein as determine by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_777596
Locus ID 255738
UniProt ID Q8NBP7
Cytogenetics 1p32.3
RefSeq Size 3636
RefSeq ORF 2076
Synonyms FH3; FHCL3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2014
Protein Categories Cardiovascular diseases, Enzyme: Peptidases, Intracellular Proteins, Secreated Proteins
Protein Families Secreted Protein
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Other "PCSK9" proteins (7)
SKU Description Size Price
PH320000 PCSK9 MS Standard C13 and N15-labeled recombinant protein (NP_777596) 10 ug
$3,360.00
LC403563 Lyophilized PCSK9 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY403563 Transient overexpression lysate of proprotein convertase subtilisin/kexin type 9 (PCSK9) (as WB positive control) 100 ug
$665.00
TP320000 Recombinant protein of human proprotein convertase subtilisin/kexin type 9 (PCSK9), 20 µg 20 ug
$867.00
TP700053 Recombinant protein of secreted form of human proprotein convertase subtilisin/kexin type 9 (PCSK9) 20 ug
$900.00
TP720768 Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9) 10 ug
$275.00
TP721051 Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9), D374Y mutant. 10 ug
$275.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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