EBI3 (NM_005755) Human Recombinant Protein

CAT#: TP723851

Purified recombinant protein of Human Epstein-Barr virus induced 3 (EBI3)


 Product Datasheet for 'TP723851'

 Cited in 1 publication.

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USD 355.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human Epstein-Barr virus induced 3 (EBI3)
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence Human IL-27, consisting two subunits, EBI3, the region of Arg21-Lys229, from gene Accession# NM_005755 , and p28, the region of Phe29-Pro243, from gene Accession# NM_145659, linked via a GS bridge
Tag C-His
Predicted MW 50 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 20 mM NaHPO4, pH6, 0.60 M NaCl.
Bioactivity The ED50 is 60 - 90 ng/ml, corresponding to a specific activity of 1.1 - 1.7 x 10^4 units/mg, determined by mouse splenocytes IL-2 inhibition induced by hIL-27 in mouse splenocytes activated with anti-CD3 and anti-CD28 antibodies.
Co-immunoprecipitation (PMID: 27019190)
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method.
Reference Data
RefSeq NP_005746
Locus ID 10148
Refseq Size 1149
Cytogenetics 19p13.3
Refseq ORF 690
Synonyms IL-27B; IL27B; IL35B
Summary This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Protein Families Druggable Genome, Secreted Protein

Citations (1)

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